Effect of prazosin GITS, atenolol, nifedipine SR, and enalapril on ADP-induced platelet aggregation
| Autor: | K C, Patki, S J, Joglekar, S K, Kamat, U M, Thatte, M E, Yeolekar, N N, Rege, S A, Dahanukar, A S, Nanivadekar |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Nifedipine Platelet Aggregation Adrenergic beta-Antagonists Angiotensin-Converting Enzyme Inhibitors Prazosin Middle Aged Calcium Channel Blockers Adenosine Diphosphate Atenolol Enalapril Delayed-Action Preparations Hypertension Humans Female Single-Blind Method Adrenergic alpha-Antagonists Antihypertensive Agents |
| Zdroj: | The Journal of the Association of Physicians of India. |
| ISSN: | 0004-5772 |
| Popis: | A randomized, observer-blind, parallel-group study was carried out to compare the effect of prazosin GITS, atenolol, nifedipine SR, and enalapril on platelet aggregation, measured at a time expected to coincide with trough plasma levels of these drugs. 24 patients (age-30 to 60 yrs) with uncomplicated mild to moderate hypertension who completed a placebo run-in phase successfully were recruited in this study. They were randomly allocated to one of the 4 treatments: prazosin GITS 2.5 mg OD (Group 1), atenolol 50 mg OD (Group II), nifedipine SR 20 mg BD (Group III), and enalapril 5 mg OD (Group IV). All the drugs were given for 7 days, and blood samples were collected at 0 hr on day 1 (pre-treatment) and day 8 (post-treatment). Based on the dose (incremental concentrations of ADP)--response (% maximum aggregation) curve obtained, 2.5 microM/L of ADP was used to compare % inhibition of platelet aggregation among the 4 groups. We found that prazosin GITS inhibited % maximum aggregation significantly (p = 0.02) at 2.5 microM/L of ADP. Such inhibitory effect was not seen in any of the other groups. The inhibition produced by prazosin GITS differed significantly from the action of the other 3 drugs (p0.05). This antiplatelet effect of prazosin GITS bears more clinical relevance in view of the fact that it was seen at a time which is expected to coincide with the trough plasma levels of prazosin. |
| Databáze: | OpenAIRE |
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