| Autor: |
M, Amico-Roxas, A, Caruso, V M, Cutuli, E, de Bernardis, G, Leonardi |
| Rok vydání: |
1993 |
| Předmět: |
|
| Zdroj: |
Drugs under experimental and clinical research. 19(5) |
| ISSN: |
0378-6501 |
| Popis: |
The effects of propionyl-L-carnitine (PLC) in various models of inflammation were studied in rats and mice. PLC (50-200 mg/kg i.p.) dose-dependently inhibited the granuloma pouch induced by croton oil in rats, but failed to inhibit either cotton pellet granuloma or carrageenin-induced paw oedema and peritonitis. PLC (100 mg/kg i.p.) significantly reduced mouse ear oedema induced by croton oil, tetradecanoylphorbol acetate and arachidonic acid; in these models, PLC concomitantly reduced plasma extravasation, as evaluated by the leakage of Evans blue. In all the tested models, L-carnitine and acetyl-L-carnitine were ineffective, suggesting a specific protective role of PLC in the vascular component of the inflammatory process. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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