| Autor: |
M-C, Baranzelli, F, Penault-Llorca, F, Revillon, G, Portefaix, F, Mishellany, M-P, Chauvet, S, Giard, M-M, Dauplat, P, Gimbergues, Y-M, Robin, J, Dauplat, J, Bonneterre |
| Jazyk: |
francouzština |
| Rok vydání: |
2010 |
| Předmět: |
|
| Zdroj: |
Bulletin du cancer. 97(3) |
| ISSN: |
1769-6917 |
| Popis: |
The intraoperative determination of axillary node micrometastasis according to the Rapid GeneSearch Breast Lymph Node (BLN) is based on RT-PCR (mRNA of mammaglobine and CK19) detects metastases0.2 mm.Eighty-three pts between November 2007 and June 2008 were included (33 from Centre Jean-Perrin and 50 from Centre Oscar-Lambret). Lymph nodes were cut in 2 mm slices, and 1 out of 2 was examined with BLN; the others were examined by imprints then histological exam with immunohistochemistry.Forteen pts had micro- or macrometastasis. Seven were positive with intraoperative imprints including six macrometastasis and one micrometastasis; seven were positive with BLN and seven at histological exam with two cases of discordance. Sensitivity was 92%, specificity 98%. Positive predictive value 92%, and negative predictive value 98%. The median time for intraoperative determination was 40 minutes for 2 SLN.Half each lymph node is study by each method. This explains the discordances observed. Limit of BLN is the absence of CTI detection; however there is no consensus about the necessity of axillary clearance in such a case.In this series BLN reduces axillary clearance and improves comfort patients. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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