| Autor: |
Youhei, Mantani, Miho, Nishida, Kyouji, Yamamoto, Kazuki, Miyamoto, Hideto, Yuasa, Natsumi, Masuda, Takuya, Omotehara, Hiroki, Tsuruta, Toshifumi, Yokoyama, Nobuhiko, Hoshi, Hiroshi, Kitagawa |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
Anatomical record (Hoboken, N.J. : 2007). 301(6) |
| ISSN: |
1932-8494 |
| Popis: |
Paneth cells secrete bactericidal substances in response to bacterial proliferation on the mucosal surface without directly contacting bacteria. However, the induction mechanism of this transient secretion has not been clarified, although nervous system and/or immunocompetent cells in the lamina propria (LP) might be involved. In this study, we ultrastructurally and immunohistochemically investigated which LP cells are localized beneath Paneth cells and examined the relationship between the Paneth cell-derived cellular processes which extended into the LP and the LP cells. The results showed that various cells-including blood capillary, subepithelial stromal cell, and nerve fiber-were present in the LP beneath Paneth cells. Endothelial cells of blood capillary were the cells most frequently found in this location; they were situated within 1 μm of the Paneth cells and possessed fenestration on the surfaces adjacent to Paneth cells. The Paneth cells rarely extended the cellular processes toward the LP across the basal lamina. Most of the cellular processes of Paneth cells contacted the subepithelial stromal cells. Immunohistochemistry revealed that the CD34 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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