| Autor: |
Kalash, Ronny, Berhane, Hebist, Goff, Julie, Houghton, Frank, Epperly, Michael W., Dixon, Tracy, Zhang, Xichen, Sprachman, Melissa M., Wipf, Peter, Franicola, Darcy, Wang, Hong, Greenberger, Joel S. |
| Jazyk: |
angličtina |
| Rok vydání: |
2013 |
| Předmět: |
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| Popis: |
Thoracic irradiation results in an acute inflammatory response, latent period, and late fibrosis. Little is known about the mechanisms involved in triggering late radiation fibrosis.Thoracic irradiated fibrosis prone C57BL/6NTac mice were followed for detectable mRNA transcripts in isolated lung cells and micro-RNA in whole-tissues, and the effect of administration of water-soluble oxetanyl sulfoxide MMS350 was studied. Marrow stromal cell motility in medium from fibrotic-phase explanted pulmonary endothelial and alveolar type-II cells was measured.RNA and micro-RNA expression in lung correlated with fibrosis. MMS350 reduced pro-fibrotic gene expression in both endothelial and alveolar type-II cells in irradiated mice. Conditioned medium from irradiated cells did not alter cell motility in vitro.These studies should facilitate identification of potential new drug targets for ameliorating irradiation-induced pulmonary fibrosis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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