Effect of cloned human interferon-alpha 2a on bovine parainfluenza-3 virus. Brief report

Autor:	P, Panigrahi, S B, Mohanty, R K, Maheshwari, R M, Friedman
Rok vydání:	1988
Předmět:	Viral Core Proteins Virus Replication Recombinant Proteins Respirovirus Parainfluenza Virus 3 Human Molecular Weight Microscopy Electron Viral Proteins Capsid Interferon Type I Morphogenesis Animals RNA Viral Cattle Cells Cultured Glycoproteins
Zdroj:	Archives of virology. 98(1-2)
ISSN:	0304-8608
Popis:	Pretreatment of bovine turbinate (BTu) cells with cloned human interferon (IFN)-alpha 2a reduced the yield of infectious bovine parainfluenza-3 virus (PI-3 V). Intracellular synthesis of HN glycoprotein was reduced on postinfection day 1 (PID 1), but it recovered to normal levels subsequently. However, reduction of this protein persisted in the released virus through PID 2. Thin section electron microscopy demonstrated a drastically reduced release of mature virions and an accumulation of viral nucleocapsids inside the cytoplasm on PID 2. These results suggest that cloned human IFN-alpha 2a affects the glycoprotein synthesis, and morphogenesis of bovine PI-3 V, and thus inhibits the release of viral particles from treated cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::f9f10370bbb332ff280dc116014118a2 https://pubmed.ncbi.nlm.nih.gov/2829793 Zobrazit plný text záznamu Full text from SpringerLink