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To characterize the electrophysiologic and histologic sequelae of linear atrial ablation utilizing an irrigated electrode. To compare "irrigated" lesions with lesions deployed using the same electrode in a non-irrigated mode.Previous reports of radiofrequency catheter ablation using an irrigated electrode have emphasized its favorable effect on lesion depth. We hypothesized that electrode irrigation would also benefit linear ablation of smooth atrial myocardium, a relatively superficial target.In healthy pigs, lesions were deployed in the right and left atria. Acutely, lesions resulting from ablation using an irrigated electrode, with radiofrequency energy titration guided by electrogram amplitude reduction, were compared to lesions using the same electrode without irrigation, with energy titration guided by electrode thermometry. Irrigated lesions were also assessed serially.Acutely, irrigated lesions formed complete conduction barriers and were uncomplicated. In contrast, non-irrigated lesions formed complete conduction barriers but were frequently complicated, exhibiting endocardial charring, barotrauma, and pericardial damage. The rate and pattern of histologic evolution of irrigated lesions were uniform throughout each lesion; right and left atrial lesions healed similarly. During healing, 90 % of lesions remained complete conduction barriers and 10 % manifested single discrete conduction gaps where viable appearing myocytes bridged the lesion.Complete, uncomplicated linear lesions could be reliably deployed in either atrium with an irrigated electrode. Not all lesions remained complete barriers to conduction during their histologic evolution. Lesions deployed with the same electrode in a non-irrigated mode were complete but frequently complicated. |
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