The association between food insulin index and odds of non-alcoholic fatty liver disease (NAFLD) in adults: a case-control study
| Autor: | Fatahi, Somaye, Sohouli, Mohammad Hassan, Rayi, Appaji, Teymoori, Farshad, Shidfar, Farzad |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Gastroenterology and Hepatology From Bed to Bench |
| ISSN: | 2008-4234 2008-2258 |
| Popis: | Aim: This research aimed to study the association of food insulin index and biochemical parameters with the odds of developing NAFLD in adult Iranians. Background: Hyperinsulinemia may play an important role in the development of non-alcoholic fatty liver disease (NAFLD) because of the relationship between insulin response and body fat accumulation. Methods: A case-control study of 169 NAFLD patients and 200 healthy adults aged 18-55 years was conducted. Dietary data was collected using a validated 168-item quantitative food frequency questionnaire (FFQ). Food insulin index (FII) was calculated by dividing the total insulin load by total energy intake (kcal/day). Total insulin load (ILoverall) was also calculated using a standard formula. Results: Mean participant age was 43.9 ± 5.9 years. Patients with NAFLD were significantly associated with higher body mass index, levels of liver enzymes, triglyceride, low density lipoprotein-cholesterol (LDL), total cholesterol, and fasting blood sugar (FBS) compared to the healthy subjects (p < 0.05). The highest tertiles of FII were associated with higher odds of NAFLD (OR=1.4, 95% CI: 0.88-2.48, p for trend |
| Databáze: | OpenAIRE |
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