Histopathological Evaluation of the Effects of CAPE in Experimental Spinal Cord Injury

Autor: Hasan Emre, Aydin, Emre, Ozkara, Zuhtu, Ozbek, Murat, Vural, Dilek, Burukoglu, Ali, Arslantas, Metin Ant, Atasoy
Rok vydání: 2016
Předmět:
Zdroj: Turkish neurosurgery. 26(3)
ISSN: 1019-5149
Popis: /BSpinal cord injuries negatively affect the individuals and the life quality of their families due to neurological deficits caused by trauma. The prevalence of spinal cord injury is 15-45/1 million in the world. Caffeic acid phenethyl ester (CAPE) is the most active component of propolis and has neuroprotective, anti-oxidant and anti-apoptotic effects. Our aim was to determine the effects of CAPE on the prevention of secondary injury and to compare with methylprednisolone.Forty rats were divided into 4 groups. The control group did not undergo surgery (Group I), only trauma group (Group II), trauma+CAPE treatment group (Group III), and trauma+methylprednisolone treatment group (Group IV). Histopathological assessment was performed with two staining methods as hematoxylin-eosin (HE) and terminal deoxynucleotidyl Transferase Biotin - dUTP Nick End Labeling (TUNEL). The groups were statistically compared.The apoptotic cells decreased in treatment groups compared with the trauma. CAPE has more anti-apoptotic effect than methylprednisolone. The histological difference between the Group II, and Groups III and IV was statistically significant.CAPE has a positive effect on spinal cord injuries by preventing apoptosis.
Databáze: OpenAIRE