[The influence of modulators of enzyme activity on the pharmacological effect of thiopental sodium and ketamine and on the pharmacokinetics of thiopental sodium]

Autor:	B I, Liubimov, A A, Pentiuk, A I, Datsiuk, R A, Musin, A N, Iavorskiĭ
Rok vydání:	1992
Předmět:	Male Enzyme Induction Animals Drug Interactions Ketamine Enzyme Inhibitors Rats Wistar Thiopental Rats
Zdroj:	Eksperimental'naia i klinicheskaia farmakologiia. 55(4)
ISSN:	0869-2092
Popis:	The rat experiments studied the impact of inductors and inhibitors of enzymatic activity of xenobiotic metabolism on the pharmacological activity of sodium thiopental and ketamine and on the pharmacokinetics of sodium thiopental. Cocarboxylase, cobalt chloride and cimetidine enhanced the pharmacological action of sodium thiopental, but failed to exert any action on the effect of ketamine. The preparations of vitamin K, particularly vikasol and menadione sodium bisulfite, and phenobarbital attenuated the effects of these anesthetics, but tocopherol unchanged it. Phenobarbital and vikasol accelerated blood elimination of sodium thiopental, whereas cimetidine and cocarboxylase slowed down this process.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::f912553ec123ce62640ed685d72aef79 https://pubmed.ncbi.nlm.nih.gov/1458188 Zobrazit plný text záznamu