| Autor: |
Rosane Borges, Dias, Taís Bacelar Sacramento, de Araújo, Raíza Dias, de Freitas, Ana Carolina Borges da Cruz, Rodrigues, Letícia Palmeira, Sousa, Caroline Brandi Schlaepfer, Sales, Ludmila de Faro, Valverde, Milena Botelho Pereira, Soares, Mitermayer Galvão, Dos Reis, Ricardo Della, Coletta, Eduardo Antônio Gonçalves, Ramos, Celso Amorim, Camara, Tania Maria Sarmento, Silva, José Maria Barbosa, Filho, Daniel Pereira, Bezerra, Clarissa Araújo Gurgel, Rocha |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Free radical biologymedicine. 126 |
| ISSN: |
1873-4596 |
| Popis: |
β-Lapachone is a natural naphthoquinone originally obtained from the bark of the purple Ipe (Tabebuia avellanedae Lor, Bignoniaceae) and its therapeutic potential in human cancer cells has been evaluated in several studies. In this study, we examined the effects of β-lapachone and its 3-iodine derivatives (3-I-α-lapachone and 3-I-β-lapachone) on cell proliferation, cell death, and cancer-related gene expression in human oral squamous cell carcinoma cells. β-Lapachone and its 3-iodine derivatives showed potent cytotoxicity against different types of human cancer cell lines. Indeed, treatment with these compounds induced cell cycle arrest at G |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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