[Isolation and structural elucidation of a bioactive saponin from tubers of Bolbostemma paniculatum]

Autor: Hai-Feng, Tang, Shu-Yu, Zhang, Yang-Hua, Yi, Ai-Dong, Wen, Yue-Ping, Zhao, Zhong-Zhuang, Wang
Rok vydání: 2006
Předmět:
Zdroj: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 31(3)
ISSN: 1001-5302
Popis: To study the bioactive constituents from tubers of Bolbostemma paniculatum.Compounds were isolated by extraction and partition as well as several-chromatographic techniques guided with Pyricularia oryzae bioassay method. Their structures were determined on the basis of spectral analysis and chemical evidence.Bisdesmoside (I) was isolated as active compound causing morphological abnormality of Pyncularia oryzae mycelia and elucidated as 3-0-alpha-L-arabinopyranosyl (1--2)-beta-D-glucopyranosyl-bayogenin-28-O-beta-D-xylopyranosyl (1--3)-alpha-L-rhamnopyranosyl (1--2)-alpha-L-arabinopyranoside.I is a new natural product and exhibited significant cytotoxicity against cancer cell lines K-562 and BEL-7402, but no hemolytic activity to rabbit erythrocytes.
Databáze: OpenAIRE