| Autor: |
Y S, Kanwar, C A, Krakower, J R, Manaligod, P, Justice, P W, Wong |
| Rok vydání: |
1975 |
| Předmět: |
|
| Zdroj: |
Biomedicine / [publiee pour l'A.A.I.C.I.G.]. 22(3) |
| ISSN: |
0300-0893 |
| Popis: |
Hyperprolinemia, hyperprolinuria and hydroxyprolinuria were observed in PRO/Re mice. Hepatic proline oxidase activity in PRO/Re mice was markedly deficient. It was demonstrated that the deficiency of proline oxidase activity was not due to the presence of an inhibitor. The mutant enzyme in PRO/Re showed no difference in heat stability but had a poor affinity for the substrate, L-proline as compared to normal enzymes. There was no significant proteinuria or hematuria in PRO/Re mice. Their serum protein and blood urea nitrogen were normal. Morphologic studies by light and electron microscopy demonstrated no abnormality in the renal tissues of PRO/Re up to 6 months of age, suggesting that hyperprolinemia did not cause renal damage. Pedigree studies showed that F1 generation (PRO/Re x CD 1) had approximately 50 percent of normal proline oxidase activity and significantly higher plasma proline. The distribution of hepatic proline oxidase activity in F2 GENERATION (F1 x F1) was characteristic of an autosomal recessive trait. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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