| Autor: |
Xiao-Xuan, Fan, Yu-Ying, Hao, Shi-Wen, Guo, Xiao-Ping, Zhao, Yi, Xiang, Fei-Xue, Feng, Ge-Ting, Liang, Yu-Wei, Dong |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Neurochemistry international. 121 |
| ISSN: |
1872-9754 |
| Popis: |
Reticulons (RTNs) are a family of membrane-bound proteins that are dominantly localized to the endoplasmic reticulum (ER) membrane. RTN1-C is one member of RTNs abundantly expressed in the brain and has been shown to mediate neuronal injury in cerebral ischemia models. In the present study, we investigated the role of RTN1-C in an in vitro brain trauma model mimicked by traumatic neuronal injury (TNI) in primary cultured cortical neurons. TNI increased the expression of RTN1-C in cortical neurons but had no effect on RTN1-A and RTN1-B. Knockdown of RTN1-C with specific siRNA (Si-RTN1-C) significantly decreased cytotoxicity and apoptosis after TNI. The results of Ca |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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