Monitoring the on-line titration of enantiomeric omeprazole employing continuous-flow capillary microcoil 1H NMR spectroscopy

Autor:	Petra, Hentschel, Karsten, Holtin, Lisa, Steinhauser, Klaus, Albert
Rok vydání:	2012
Předmět:	Magnetic Resonance Spectroscopy Stereoisomerism Anti-Ulcer Agents Dimerization Omeprazole
Zdroj:	Chirality. 24(12)
ISSN:	1520-636X
Popis:	The titration of the (S)-enantiomer of omeprazole with the (R)-enantiomer in chloroform-d(1) is monitored by continuous-flow capillary microcoil (1)H NMR spectroscopy employing a microcoil with a detection volume of 1.5 µl. The observed changes of the (1)H NMR chemical shifts indicate the formation of a heterochiral (R,S) dimer of omeprazole via its sulfinyl group and the NH group of the benzimidazole ring.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::f8b2baa193b9d4a736dbdb304b166377 https://pubmed.ncbi.nlm.nih.gov/22887745 Zobrazit plný text záznamu Plný text