| Autor: |
F, Salaffi, A, Migliore, M, Scarpellini, S M, Corsaro, B, Laganà, F, Mozzani, G, Varcasia, M, Pusceddu, G, Pomponio, N, Romeo, A, Maier, Rosario, Foti, Raffaele, Scarpa, Stefania, Gasparini, Stefano, Bombardieri |
| Rok vydání: |
2009 |
| Předmět: |
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| Zdroj: |
Clinical and experimental rheumatology. 28(2) |
| ISSN: |
0392-856X |
| Popis: |
To evaluate the psychometric properties of an index based on 3 patient reported outcomes measures, termed PRO-CLinical ARthritis Activity (PRO-CLARA), in order to facilitate rapid and easy rheumatoid arthritis (RA) activity assessment in daily routine.196 patients partially or not responding to disease modifying anti-rheumatic drugs (DMARDs), consented to participate in a multicentre cross-sectional study. For the evaluation of the psychometric properties of the PRO-CLARA, this population has been compared to another cohort of 247 outpatients with RA who were participating in a long-term observational study and who satisfying minimal disease activity and remission definitions. All patients completed the PRO-CLARA, combining patient's physical function, self-administered tender joint count and perception of global health status into a single measure of disease activity. Additional comparator composite indices were analysed. Internal consistency was assessed with Cronbach's alpha coefficient. A confirmatory factor analysis was carried out to test factor structure. Concurrent validity was analyzed using Spearman's correlations and cross-tabulations. Discriminant validity to distinguish patients with active and non-active disease was assessed with receiver operating characteristic (ROC) curve analysis. For agreement analysis, kappa statistics were calculated.In testing for internal consistency, we found that Cronbach's alpha for the PRO-CLARA was 0.893, indicating high reliability. PRO-CLARA proved to be significantly correlated to established RA activity assessment tools. The area under ROC curve of the PRO-CLARA gives identical results to those provided by other comparator indices.The study showed satisfactory psychometric properties of the PRO-CLARA. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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