Membrane glycoproteins of Newcastle disease virus: nucleotide sequence of the hemagglutinin-neuraminidase cloned gene and structure/function relationship of predicted amino acid sequence

Autor:	A, Sagrera, C, Cobaleda, J M, González De Buitrago, A, García-Sastre, E, Villar
Rok vydání:	2002
Předmět:	Structure-Activity Relationship Glycosylation HN Protein Membrane Glycoproteins Base Sequence Molecular Sequence Data Newcastle disease virus Amino Acid Sequence Cloning Molecular Hydrophobic and Hydrophilic Interactions Protein Structure Secondary
Zdroj:	Glycoconjugate journal. 18(4)
ISSN:	0282-0080
Popis:	The nucleotide sequence of the glycoprotein hemagglutinin-neuraminidase (HN) gene of the Newcastle disease virus (NDV) strain Clone-30 has been determined. The open reading frame of the HN gene contains 1731 nucleotides and encodes a protein of 577 amino acids. Three highly conserved patterns among all paramyxovirus HN glycoproteins, and one additional conserved species-specific region are present. The protein contains five potential N-glycosylation sites, all but one located in the C-terminal external domain. The secondary structure prediction shows that the C-terminal external domain is mostly arranged in beta-sheets, while alpha-helices are predominantly located in the N-terminal domain. The nucleotide sequence data of the HN gene reported in this paper has been deposited in the GenBank database, under accession number AF098289.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::f8650819af265b6f8ae13559815a9a9d https://pubmed.ncbi.nlm.nih.gov/11788796 Zobrazit plný text záznamu Full text from SpringerLink