| Autor: |
V M, Podboronov, V M, Bondarenko, I M, Grokhovskaia, T V, Zhuravleva, T A, Revina |
| Rok vydání: |
1978 |
| Předmět: |
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| Zdroj: |
Antibiotiki. 23(8) |
| ISSN: |
0003-5637 |
| Popis: |
The cytotoxic effect on Argasidae lysozyme was shown on a model of cell line HEp-2 in comparison to egg lysozyme. The lysozyme was obtained from homogenates of Ornithodoros papillipes of subfamily Ikodoidea. The lysozyme in concentrations of 300 and 500 gamma/ml had a cytotoxic effect, while in doses of 50 and 100 gamma/ml it has no such activity. The cells of line FL were not sensitive to the above concentrations of the lysozyme. In concentrations of 500 gamma/ml and higher the egg lysozyme had an analogous cytotoxic effect on the cells of line Hep-2. The comparative study of the cariogrammes of the cell monolayer treated with the Argasidae and egg lysozymes, as well as the study of the level of 3H-thimidine incorporation into the cell DNA showed the absence of the preparations effect of the mitotic activity of the cells and DNA synthesis by them. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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