Prostacyclin (prostaglandin I2) formation in lung tissues of infants in sudden infant death syndrome (SIDS), non-SIDS and adults

Autor: D S, Seto, M, Matsuo, J L, Hokama, L K, Shirai, Y, Hokama
Rok vydání: 1983
Předmět:
Zdroj: Journal of medicine. 14(5-6)
ISSN: 0025-7850
Popis: SIDS lung tissues elaborated significantly (p less than 0.01) lower PGI2 as compared with non-SIDS and adults. Significant differences (p less than 0.01) between SIDS and non-SIDS were especially shown at 2-4 months of age, 16.46 +/- 6.86 vs. 28.39 +/- 8.86 ng PGI2/50 mg of lung tissue, respectively, for SIDS and non-SIDS. A highly significant difference (p less than 0.001) was shown for SIDS (16.46 +/- 6.86 ng PGI2/50 mg lung tissue) when compared to adults (33.50 +/- 5.60 ng PGI2/50 mg lung tissue). It is suggested that there is defective maturation in the development of prostacyclin synthetase in lung tissues of SIDS infants.
Databáze: OpenAIRE