| Autor: |
K D, Rehm, K, Schnelle, C J, Dyde, E, Blümner, W, Arendts |
| Jazyk: |
němčina |
| Rok vydání: |
1987 |
| Předmět: |
|
| Zdroj: |
Arzneimittel-Forschung. 37(9) |
| ISSN: |
0004-4172 |
| Popis: |
Sotalol (Sotalex; Sotacor) is a beta-blocker with additional class III antiarrhythmic activity. In this study two intravenous doses of 1.5 mg/kg and 2 mg/kg body weight were administered in 8 healthy volunteers in order to determine the pharmacokinetics and ECG intervals. After a short-term infusion (5 min) plasma levels and the relevant pharmacokinetic parameters were determined. The ECG parameters (QRS, PQ, QT, QTc), blood pressure, heart rate and tolerability were also evaluated. A correlation between the plasma concentration of sotalol, the decrease in heart rate and a prolongation of the real QT interval was found for both dose levels and for a period of 2 h after administration. A prolongation of the QTc-time could only be statistically confirmed for the higher dose. No differences in pharmacokinetic parameters were observed between the two doses. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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