| Autor: |
Amber L H, Gray, Carlos A, Steren, Isaac W, Haynes, Guillermo A, Bermejo, Filippo, Favretto, Markus, Zweckstetter, Thanh D, Do |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
The journal of physical chemistry. B. 125(5) |
| ISSN: |
1520-5207 |
| Popis: |
Falling outside of Lipinski's rule of five, macrocyclic drugs have accessed unique binding sites of their target receptors unreachable by traditional small molecules. Cyclosporin(e) A (CycA), an extensively studied macrocyclic natural product, is an immunosuppressant with undesirable side effects such as electrolytic imbalances. In this work, a comprehensive view on the conformational landscape of CycA, its interactions with Ca |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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