| Autor: |
Wang, Xin-Shuai, Zhao, Meng-Qi, Zhang, Li, Kong, De-Jiu, Ding, Xue-Zhen, Hu, Xiao-Chen, Yang, Jun-Qiang, Gao, She-Gan |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
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| Popis: |
Objective: To assess the diagnostic performance of cell-free DNA assays in the detection of bladder cancer. Patients and methods: The quality of the studies included in this meta-analysis was assessed using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool. Statistical analyses were performed using the software RevMan 5.3 and Stata 14.0. We assessed the pooled sensitivity and specificity, positive/negative likelihood ratios (PLRs/NLRs), diagnostic odds ratios (DORs), and corresponding 95% confidence intervals (95% CIs). Summary receiver operating characteristic curve (ROC curve) and area under the curve (AUC) were used to summarize the overall test performance. Heterogeneity and publication bias were also examined. Results: Eleven studies included 802 bladder cancer patients and 668 controls met the eligibility criteria. The overall diagnostic accuracy was measured as follows: sensitivity 0.71 (95% CI = 0.64-0.77), specificity 0.78 (95% CI = 0.70-0.85), PLR 3.3 (95% CI = 2.4-54.5), NLR 0.37 (95% CI = 0.30-0.46), DOR 9 (95% CI = 6-14), and AUC 0.80 (95% CI = 0.77-0.83). Subgroup analysis suggested that ethnicity significantly accounted for the heterogeneity of specificity. The Deeks’ funnel plot asymmetry test (P = 0.97) suggested no potential publication bias. Conclusions: Cell-free DNA has a high diagnostic value in bladder cancer. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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