| Autor: |
Adriele Dandara, Levorato-Vinche, Marcia de Souza Carvalho, Melhem, Lucas Xavier, Bonfietti, Iván, de-la-Cruz-Chacón, Carmen Sílvia Fernandes, Boaro, Alexandre Todorovic, Fabro, Gisela, Ferreira, Julhiany de Fátima, da Silva, Daniela Carvalho, Dos Santos, Beatriz Aparecida Soares, Pereira, Camila, Marçon, Lariza, Maza, Lídia Raquel, de Carvalho, Rinaldo Poncio, Mendes |
| Rok vydání: |
2022 |
| Zdroj: |
The journal of venomous animals and toxins including tropical diseases. 28 |
| ISSN: |
1678-9199 |
| Popis: |
Cryptoccocal meningitis continues to present high incidence among AIDS patients. The treatment of choice is the synergistic combination of flucytosine (5-FC) with amphotericin B deoxycholate (AmBd) or its lipid formulations. However, 5-FC is unavailable in many countries and AmB demands hospitalization. The combination of AmB with the fungistatic fluconazole (FLC) or the use of high FLC daily doses alone became the choice. Nonetheless, sterilization of cerebrospinal fluid is delayed with FLC monotherapy, mainly with high fungal burden. These findings suggest the search for new antifungal compounds, such as liriodenine.Liriodenine antifungal activity was evaluated by three procedures: determining the minimum inhibitory concentration (MIC) on 30 strains of theLiriodenine MICs ranged from 3.9 to 62.5 μg.mLThe fungicidal activity confirmed by time-kill methodology, the intense |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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