C1qR(P), a myeloid cell receptor in blood, is predominantly expressed on endothelial cells in human tissue
| Autor: | M I, Fonseca, P M, Carpenter, M, Park, G, Palmarini, E L, Nelson, A J, Tenner |
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| Rok vydání: | 2001 |
| Předmět: |
Umbilical Veins
Neutrophils Recombinant Fusion Proteins Nerve Tissue Proteins CHO Cells Spodoptera Transfection Monocytes Immunoenzyme Techniques Mitochondrial Proteins Mice Cricetulus Phagocytosis Cricetinae Animals Humans Membrane Glycoproteins Tumor Necrosis Factor-alpha Macrophages Myocardium Pyramidal Cells Cell Differentiation Dendritic Cells U937 Cells Nucleopolyhedroviruses Capillaries Neoplasm Proteins Rats Receptors Complement Viscera Hyaluronan Receptors Gene Expression Regulation Organ Specificity Macrophages Peritoneal Endothelium Vascular Microglia Carrier Proteins |
| Zdroj: | Journal of leukocyte biology. 70(5) |
| ISSN: | 0741-5400 |
| Popis: | C1qR(P) is a type I cell surface glycoprotein that has been shown to enhance ingestion of suboptimally opsonized targets by phagocytes in vitro. In this study, we developed and characterized polyclonal antibodies to study the tissue distribution of this receptor targeted to either the N- or C-terminal portion of the molecule. C1qR(P) was detected in vascular endothelial cells and in a subset of pyramidal neurons in the brain, as well as neutrophils, but it was absent in most tissue macrophages. Analysis of in vitro differentiation of blood monocytes to dendritic cells demonstrated a down-regulation of the receptor as monocytes differentiate to dendritic cells, providing a possible explanation for the lack of reactivity of these cells in tissue. The predominant presence of C1qR(P) in endothelial cells, while compatible with a phagocytic role in host defense and/or clearance of cellular material, suggests other possible novel roles for this receptor. |
| Databáze: | OpenAIRE |
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