Stability of the radiopharmaceutical [99mTc]DMSA: study of the ligand exchange reaction with [99Tc]EDTA

Autor: M, Garcia Muñoz, R, Garcia Domenech, J, Galvez Alvarez, J, Moreno Frigols
Rok vydání: 1983
Předmět:
Zdroj: The International journal of applied radiation and isotopes. 34(11)
ISSN: 0020-708X
Popis: A kinetic study was made of the ligand exchange reaction between [99mTc]EDTA and DMSA. The results of this study indicate that this exchange reaction is closely related to temperature and pH. Kinetic and thermodynamic parameters demonstrate that both complexes--[99MTc]EDTA and [99mTc]DMSA--have a similar stability. Furthermore, the existence of an acid-basic catalysis for the global exchange reaction was established, and the catalytic parameters were calculated. These data were obtained by radiochromatography and visible spectrophotometry.
Databáze: OpenAIRE