| Autor: |
Vijay M, Ravindra, Robert J, Bollo, Michael C, Dewan, Jay K, Riva-Cambrin, Daniel, Tonetti, Al-Wala, Awad, S Hassan, Akbari, Stephen, Gannon, Chevis, Shannon, Yekaterina, Birkas, David, Limbrick, Andrew, Jea, Robert P, Naftel, John R, Kestle, Ramesh, Grandhi |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery. 37(1) |
| ISSN: |
1433-0350 |
| Popis: |
Blunt cerebrovascular injury (BCVI) is uncommon in the pediatric population. Among the management options is medical management consisting of antithrombotic therapy with either antiplatelets or anticoagulation. There is no consensus on whether administration of antiplatelets or anticoagulation is more appropriate for BCVI in children10 years of age. Our goal was to compare radiographic and clinical outcomes based on medical treatment modality for BCVI in children10 years.Clinical and radiographic data were collected retrospectively for children screened for BCVI with computed tomography angiography at 5 academic pediatric trauma centers.Among 651 patients evaluated with computed tomography angiography to screen for BCVI, 17 patients aged less than 10 years were diagnosed with BCVI (7 grade I, 5 grade II, 1 grade III, 4 grade IV) and received anticoagulation or antiplatelet therapy for 18 total injuries: 11 intracranial carotid artery, 4 extracranial carotid artery, and 3 extracranial vertebral artery injuries. Eleven patients were treated with antiplatelets (10 aspirin, 1 clopidogrel) and 6 with anticoagulation (4 unfractionated heparin, 2 low-molecular-weight heparin, 1 transitioned from the former to the latter). There were no complications secondary to treatment. One patient who received anticoagulation died as a result of the traumatic injuries. In aggregate, children treated with antiplatelet therapy demonstrated healing on 52% of follow-up imaging studies versus 25% in the anticoagulation cohort.There were no observed differences in the rate of hemorrhagic complications between anticoagulation and antiplatelet therapy for BCVI in children10 years, with a nonsignificantly better rate of healing on follow-up imaging in children who underwent antiplatelet therapy; however, the study cohort was small despite including patients from 5 hospitals. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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