Endonuclease G modulates the alternative splicing of deoxyribonuclease 1 mRNA in human CD4

Autor:	Dmitry D, Zhdanov, Yulia A, Gladilina, Vadim S, Pokrovsky, Dmitry V, Grishin, Vladimir A, Grachev, Valentina S, Orlova, Marina V, Pokrovskaya, Svetlana S, Alexandrova, Anna A, Plyasova, Nikolay N, Sokolov
Rok vydání:	2018
Předmět:	Adult CD4-Positive T-Lymphocytes Male Alternative Splicing Endodeoxyribonucleases Adolescent Deoxyribonuclease I Humans Apoptosis Female RNA Messenger
Zdroj:	Biochimie. 157
ISSN:	1638-6183
Popis:	Apoptotic endonucleases act cooperatively to fragment DNA and ensure the irreversibility of apoptosis. However, very little is known regarding the potential regulatory links between endonucleases. Deoxyribonuclease 1 (DNase I) inactivation is caused by alternative splicing (AS) of DNase I pre-mRNA skipping exon 4, which occurs in response to EndoG overexpression in cells. The current study aimed to determine the role of EndoG in the regulation of DNase I mRNA AS and the modulation of its enzymatic activity. A strong correlation was identified between the EndoG expression levels and DNase I splice variants in human lymphocytes. EndoG overexpression in CD4
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::f6dd5c2c69281a07102e77915edd2b98 https://pubmed.ncbi.nlm.nih.gov/30521874 Zobrazit plný text záznamu Full Text from ScienceDirect