A novel rat model of thrombogenicity: its use in evaluation of prothrombin complex concentrates and high purity factor IX concentrates

Autor:	L F, McLaughlin, O, Drummond, I R, MacGregor
Rok vydání:	1992
Předmět:	Factor IX Rats Sprague-Dawley Disease Models Animal Fibrin Dose-Response Relationship Drug Animals Female Prothrombin Thrombosis Fibrinopeptide A Rats
Zdroj:	Thrombosis and haemostasis. 68(5)
ISSN:	0340-6245
Popis:	A non-stasis rodent model of thrombogenicity has been used for dose-ranging studies with a conventional prothrombin complex concentrate (PCC) and to evaluate high purity factor IX concentrates from different manufacturers. Fibrin monomer (soluble fibrin) and fibrinopeptide A (FPA) were monitored before and after infusion of test solution. FPA was found to be the more sensitive and reproducible indicator of thrombogenicity and exhibited a dose-related elevation after infusion of the PCC at doses of between 100-300 IU/kg. In contrast the amounts of FPA generated after 300 IU/kg of the high purity factor IX products were similar to control infusions of albumin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::f6c6512e384201ea7c764ba156fc147d https://pubmed.ncbi.nlm.nih.gov/1455396 Zobrazit plný text záznamu