Physical training prevents oxidative stress in L-NAME-induced hypertension rats
| Autor: | Andréia Machado, Cardoso, Caroline Curry, Martins, Fernando da Silva, Fiorin, Roberta, Schmatz, Fátima Husein, Abdalla, Jessié, Gutierres, Daniela, Zanini, Amanda Maino, Fiorenza, Naiara, Stefanello, Jonas Daci da Silva, Serres, Fabiano, Carvalho, Verônica Paiva, Castro, Cinthia Melazzo, Mazzanti, Luiz Fernando Freire, Royes, Adriane, Belló-Klein, Jeferson Ferraz, Goularte, Vera Maria, Morsch, Margarete Dulce, Bagatini, Maria Rosa Chitolina, Schetinger |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Superoxide Dismutase Systole Body Weight Blood Pressure Ascorbic Acid Catalase Kidney Nitric Oxide Lipids Thiobarbituric Acid Reactive Substances Rats Protein Carbonylation Oxidative Stress NG-Nitroarginine Methyl Ester Heart Rate Physical Conditioning Animal Hypertension Animals Lipid Peroxidation Sulfhydryl Compounds Rats Wistar Oxidation-Reduction Biomarkers Swimming |
| Zdroj: | Cell biochemistry and function. 31(2) |
| ISSN: | 1099-0844 |
| Popis: | The present study investigated the effects of a 6-week swimming training on blood pressure, nitric oxide (NO) levels and oxidative stress parameters such as protein and lipid oxidation, antioxidant enzyme activity and endogenous non-enzymatic antioxidant content in kidney and circulating fluids, as well as on serum biochemical parameters (cholesterol, triglycerides, urea and creatinine) from Nω-nitro-L-arginine methyl ester hydrochloride (L-NAME)-induced hypertension treated rats. Animals were divided into four groups (n = 10): Control, Exercise, L-NAME and Exercise L-NAME. Results showed that exercise prevented a decrease in NO levels in hypertensive rats (P0·05). An increase in protein and lipid oxidation observed in the L-NAME-treated group was reverted by physical training in serum from the Exercise L-NAME group (P0·05). A decrease in the catalase (CAT) and superoxide dismutase (SOD) activities in the L-NAME group was observed when compared with normotensive groups (P0·05). In kidney, exercise significantly augmented the CAT and SOD activities in the Exercise L-NAME group when compared with the L-NAME group (P0·05). There was a decrease in the non-protein thiols (NPSH) levels in the L-NAME-treated group when compared with the normotensive groups (P0·05). In the Exercise L-NAME group, there was an increase in NPSH levels when compared with the L-NAME group (P0·05). The elevation in serum cholesterol, triglycerides, urea and creatinine levels observed in the L-NAME group were reverted to levels close to normal by exercise in the Exercise L-NAME group (P0·05). Exercise training had hypotensive effect, reducing blood pressure in the Exercise L-NAME group (P0·05). These findings suggest that physical training could have a protector effect against oxidative damage and renal injury caused by hypertension. |
| Databáze: | OpenAIRE |
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