Performance of cardiac PET/CT with and without phase analysis for detection of scar in cardiac sarcoidosis: Comparison to cardiac magnetic resonance imaging

Autor:	Mohamed Y, Elwazir, Jared G, Bird, Omar F, AbouEzzeddine, Panithaya, Chareonthaitawee, Lori A, Blauwet, Jeremy D, Collins, Raymond J, Gibbons, Martin, Rodriguez-Porcel, Hanan M, Kamal, Ahmed T, Abdellah, John P, Bois
Rok vydání:	2020
Předmět:	Cicatrix Myocarditis Sarcoidosis Fluorodeoxyglucose F18 Positron Emission Tomography Computed Tomography Contrast Media Humans Gadolinium Magnetic Resonance Imaging
Zdroj:	Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. 29(3)
ISSN:	1532-6551
Popis:	The presence of myocardial scar in CS patients results in poor prognosis and worse outcomes.176 patients who underwent cardiac magnetic resonance (CMR) and N-13 ammonia/Sensitivity of PET/CT for scar detection was 45.3% (specificity 88.9%). Addition of PET-derived LV volumes and function in a logistic regression model improved sensitivity to 57.0% (specificity: 80.0%, AUC 0.72). Addition of phase analysis maximum segmental onset of myocardial contraction 61 improved AUC to 0.75, correctly relabeling 16.3% of patients as scar (net reclassification index 8.2%).Sensitivity of gated PET MPI alone for scar detection in CS is suboptimal. Adding PET-derived volumes/function and phase analysis data results in improved detection and characterization of scar.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::f6b49f1bde56f178f02f035dd3b4df89 https://pubmed.ncbi.nlm.nih.gov/33502697 Zobrazit plný text záznamu Full text from SpringerLink