Photo-catalyzed TiO

Autor: Yimin, Tong, Gansheng, Shi, Gaowei, Hu, Xiaoyou, Hu, Lin, Han, Xiaofeng, Xie, Yongfen, Xu, Rong, Zhang, Jing, Sun, Jin, Zhong
Rok vydání: 2020
Předmět:
Zdroj: Chemical Engineering Journal
ISSN: 1385-8947
Popis: Graphical abstract
Previous observations have been reported that viruses were inactivated using strong irradiation. Here, new evidence was disclosed by studying the effects of nanosized TiO2 on viral pathogens under a low irradiation condition (0.4 mW/cm2 at UVA band) that mimics the field setting. We showed that photo-activated TiO2 efficiently inhibits hepatitis C virus infection, and weak indoor light with intensity of 0.6 mW/cm2 at broad-spectrum wavelength and around 0.15 mW/cm2 of UVA band also lead to partial inhibition. Mechanistic studies demonstrated that hydroxyl radicals produced by photo-activated TiO2 do not destroy virion structure and contents, but attack viral RNA genome, thus inactivating the virus. Furthermore, we showed that photo-activated TiO2 inactivates a broad range of human viral pathogens, including SARS-CoV-2, a novel coronavirus responsible for the ongoing COVID-19 pandemic. In conclusion, we showed that photo-catalyzed nanosized TiO2 inactivates pathogenic viruses, paving a way to its field application in control of viral infectious diseases.
Databáze: OpenAIRE
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