IL-1-mediated inhibition of IL-6-induced STAT3 activation is modulated by IL-4, MAP kinase inhibitors and redox state of HepG2 cells
| Autor: | Jarosław, Cisowski, Adrian, Zarebski, Aleksander, Koj |
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| Rok vydání: | 2002 |
| Předmět: |
Flavonoids
STAT3 Transcription Factor Interleukin-6 Pyridines Anti-Inflammatory Agents Imidazoles Receptor Cross-Talk Antioxidants DNA-Binding Proteins Trans-Activators Humans Interleukin-4 Enzyme Inhibitors Mitogen-Activated Protein Kinases Oxidation-Reduction Cells Cultured Interleukin-1 Signal Transduction |
| Zdroj: | Folia histochemica et cytobiologica. 40(4) |
| ISSN: | 0239-8508 |
| Popis: | It is known that during acute phase reaction IL-6 activates STAT3 in hepatoma cells and IL-1 downregulates this response. We found that the inhibitory properties of IL-1 on STAT signalling cascade in human hepatoma HepG2 cells are considerably decreased not only in the presence of MAP kinase inhibitors SB203580 and PD98059 but also by some antioxidants (N-acetyl cysteine and pyrrolidine dithiocarbamate) and by anti-inflammatory cytokine IL-4. It appears that cytokine crosstalk between IL-6 and IL-1 includes a direct pathway sensitive to antioxidants and MAP kinase inhibitors, whereas the indirect prolonged response depends probably on synthesis of suppressors of cytokine signalling (SOCS). |
| Databáze: | OpenAIRE |
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