| Autor: |
Matic, Srdič, Nico D, Fessner, Deniz, Yildiz, Anton, Glieder, Markus, Spiertz, Ulrich, Schwaneberg |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Biomolecules. 12(2) |
| ISSN: |
2218-273X |
| Popis: |
Polycyclic aromatic hydrocarbons (PAHs) and their N- and O-containing derivatives (N-/O-PAHs) are environmental pollutants and synthetically attractive building blocks in pharmaceuticals. Functionalization of PAHs can be achieved via C-H activation by cytochrome P450 enzymes (e.g., P450 CYP3A4) in an environmentally friendly manner. Despite its broad substrate scope, the contribution of CYP3A4 to metabolize common PAHs in humans was found to be small. We recently showcased the potential of CYP3A4 in whole-cell biocatalysis with recombinant yeast |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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