The possible role of autoimmunity in the pathogenesis of diabetes in B-thalassemia major
| Autor: | L, Monge, S, Pinach, L, Caramellino, M T, Bertero, A, Dall'omo, Q, Carta |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Glutamate Decarboxylase Histocompatibility Testing Insulin Antibodies beta-Thalassemia Autoimmunity HLA-DR Antigens Cohort Studies Islets of Langerhans Cross-Sectional Studies Antibodies Antinuclear HLA-DQ Antigens Glucose Intolerance Diabetes Mellitus HLA-DQ beta-Chains Humans Blood Transfusion Female Autoantibodies |
| Zdroj: | Diabetesmetabolism. 27(2 Pt 1) |
| ISSN: | 1262-3636 |
| Popis: | To evaluate the possible role of autoimmunity in the pathogenesis of diabetes associated with B-thalassemia, we studied a cohort of 53 B-thalassemic individuals, under long term blood transfusion, that included twelve patients with diabetes (22.6%).To evaluate the activation of an autoimmune response, individuals were tested for islet cell antibodies (ICA), glutamic acid decarboxylase (GAD) autoantibodies, insulin autoantibodies (IAA) and serum anti-nuclear antibodies (ANA).Nine of the total B-thalassemic population (16.98%) were ICA-positive. The frequency of ICA-positive subjects among thalassemic individuals was higher than in the general population. Five (41.6%) of the ICA-positive individuals were diabetic. Of these, three were serum C-peptide-negative (0.21 nmol/l). HLA class II typing of our thalassemic population did not reveal significantly different allelic frequencies with respect to the control population.Our study demonstrates evidence of immune system activation against pancreatic B-cells in B-thalassemia and we propose that iron deposition may, through oxidative damage, act as an environmental factor that triggers the autoimmune response. Therefore, we speculate that pancreatic autoimmunity may contribute to selective B-cells damage in the pathogenesis of diabetes associated with B-thalassemia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|