A new substance effective against transplantable tumors in vivo: L-cystine-bis-(N,N-beta-chloroethyl)-hydrazide

Autor:	E V, Golovinsky, B V, Alexiev, A V, Spassov, S B, Stoev, E A, Emanuilov, I I, Angelov, L S, Maneva, T S, Stoychev
Rok vydání:	1977
Předmět:	Mice Inbred BALB C Alkylation Neoplasms Experimental Rats Lethal Dose 50 Mice Nitrogen Mustard Compounds Cats Animals Cystine Transplantation Homologous Sarcoma Experimental Carcinoma Ehrlich Tumor Multiple Myeloma Neoplasm Transplantation
Zdroj:	Neoplasma. 24(4)
ISSN:	0028-2685
Popis:	It is shown that L-cystine-bis-(N,N-beta-chloroethyl)-hydrazide-hydro-bromide possesses strong (50-100%) inhibitory effect in vivo against myeloma P-8, carcinosarcoma Walker, lymphosarcoma Pliss, sarcoma Yoshida, sarcoma Jensen and sarcoma 180 in doses 5-12 mg/kg/day. No suppression of the growth of Ehrlich ascites tumor was observed. The acute toxicity (LD50) of this substance on mice and rats is 71 mg/kg and 47 mg/kg respectively.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::f5bbe00f0b57d5a56fe1e3173dc13860 https://pubmed.ncbi.nlm.nih.gov/904741 Zobrazit plný text záznamu