Decalin-type acetylcholine-mimetic organophosphates as inhibitors of acetylcholinesterase

Autor:	Stefan, Furegati, Fabrizio, Gorla, Anthony, Linden, Peter, Rüedi
Rok vydání:	2006
Předmět:	Kinetics Structure-Activity Relationship Organophosphorus Compounds Molecular Structure Molecular Mimicry Acetylcholinesterase Cholinesterase Inhibitors Naphthalenes Crystallography X-Ray Acetylcholine
Zdroj:	Chemico-biological interactions.
ISSN:	0009-2797
Popis:	The novel decalin-type N,O,P-heterocycles, P(3)-axially and P(3)-equatorially substituted cis- and trans-configurated 3-fluoro-2,4-dioxa-7-aza-, 2,4-dioxa-8-aza-, and 2,4-dioxa-9-aza-3-phosphabicyclo[4.4.0]decane 3-oxides, are configuratively fixed and conformationally constrained phosphorus analogues of acetylcholine. The compounds are suitable probes for the investigation of molecular interactions with acetylcholinesterase.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::f5af7df5ac8918e58bbcf0d902f6213d https://pubmed.ncbi.nlm.nih.gov/16429565 Zobrazit plný text záznamu Full Text from ScienceDirect