| Autor: |
Anne Katherine C, Gomes, Mariana, Alves Soares, Ana Luísa P, Miranda, Jorge Luiz Mendonça, Tributino, Rodolfo, Goetze Fiorot, Ricardo Machado, Kuster, Anne Caroline C, Gomes, Naomi Kato, Simas |
| Rok vydání: |
2022 |
| Zdroj: |
Natural product research. |
| ISSN: |
1478-6427 |
| Popis: |
Opioid receptors mediate antinociceptive effects. Methanolic fractions from sugarcane varieties (MFSCf) were evaluated in classic nociception models. Interactions between bioactive compounds and the µ-opioid receptor (µOR) through docking analysis were also studied. Five methanolic fractions of sugarcane juice were obtained and analysed by LC-ESI-MS/MS. The fractions and standards of phenolic compounds were evaluated in a nociception model using the formalin test. All MFSCfs exhibited antinociceptive activity in the first phase of the formalin test. Docking analyses corroborates with the |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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