| Autor: |
Ruth, Eichner, Vanesa, Fernández-Sáiz, Bianca-Sabrina, Targosz, Florian, Bassermann |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
International review of cell and molecular biology. 343 |
| ISSN: |
1937-6448 |
| Popis: |
Multiple myeloma (MM) is the second most common hematological malignancy and results from the clonal amplification of plasma cells. Despite recent advances in treatment, MM remains incurable with a median survival time of only 5-6years, thus necessitating further insights into MM biology and exploitation of novel therapeutic approaches. Both the ubiquitin proteasome system (UPS) and the PI3K/Akt/mTOR signaling pathways have been implicated in the pathogenesis, and treatment of MM and different lines of evidence suggest a close cross talk between these central cell-regulatory signaling networks. In this review, we outline the interplay between the UPS and mTOR pathways and discuss their implications for the pathophysiology and therapy of MM. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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