| Autor: |
Cao, Shugeng, Brodie, Peggy, Callmander, Martin, Randrianaivo, Richard, Razafitsalama, Jeremi, Rakotobe, Etienne, Rasamison, Vincent E., TenDyke, Karen, Shen, Yongchun, Suh, Edward M., Kingston, David G. I. |
| Jazyk: |
angličtina |
| Rok vydání: |
2009 |
| Předmět: |
|
| Popis: |
Bioassay-guided fractionation of an EtOH extract obtained from the roots of the Madagascan plant Dodonaea viscosa led to the isolation of two new antiproliferative oleanane-type triterpenoid saponins, dodoneasides A and B (1 and 2). The structures of these two new compounds were elucidated using 1D and 2D NMR experiments and mass spectrometry. Compounds 1 and 2 showed antiproliferative activity against the A2780 human ovarian cancer cell line with IC(50) values of 0.79 and 0.70 muM, respectively. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
