| Autor: |
Matteus, Krappitz, Rishi, Bhardwaj, Ke, Dong, Tobias, Staudner, Duygu Elif, Yilmaz, Carlotta, Pioppini, Parisa, Westergerling, David, Ruemmele, Till, Hollmann, Thuy Anh, Nguyen, Yiqiang, Cai, Anna-Rachel, Gallagher, Stefan, Somlo, Sorin, Fedeles |
| Rok vydání: |
2021 |
| Zdroj: |
Journal of the American Society of Nephrology : JASN. |
| ISSN: |
1533-3450 |
| Popis: |
Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations inWe engineered aExpression of active XBP1 in cultured cells bearing PC1Modulating ER chaperone function through XBP1 activity improved Pkd in a murine model of PC1, suggesting therapeutic targeting of hypomorphic mutations. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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