[Two new asterosaponins from the antarctic starfish Diplasterias brucei. Structures and cytotoxic activities]

Autor:	N V, Ivanchina, T V, Maliarenko, A A, Kicha, A I, Kalinovskiĭ, P S, Dmitrenok, S P, Ermakova
Rok vydání:	2011
Předmět:	Starfish Molecular Structure Cell Line Tumor Animals Humans Antineoplastic Agents Saponins Nuclear Magnetic Resonance Biomolecular
Zdroj:	Bioorganicheskaia khimiia. 37(4)
ISSN:	0132-3423
Popis:	Two new asterosaponins, diplasteriosides A and B, with the same oligosaccharide chains beta-D-Fucp-(1--2)-beta-D-Galp-(1--4)-[beta-D-Quip-(1--2)]-beta-D-Quip-(1--3)-beta-D-Quip-(1--, linked to C6 of known genins, 3-O-sulfates of thornasterols A and B, respectively, were isolated along with the previously known asteriidoside A from the Antarctic starfish Diplasterias brucei. The structures of new compounds were elucidated by spectroscopic methods (mainly 2D NMR and mass spectrometry). The cytotoxicity of isolated asterosaponins against human colon cancer cell line HCT-116, human breast cancer cell line T-47D, and human melanoma cancer cell line RPMI-7951 was investigated.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::f49bd3ddbfcc92fc6942792736eb984d https://pubmed.ncbi.nlm.nih.gov/22096999 Zobrazit plný text záznamu