Correlation of prognostic factors and blood lymphocyte subtypes in non-Hodgkin's lymphoma

Autor:	J L, Murray, P E, Hurtubise, D C, Young, S P, Balcerzak, A F, Lobuglio
Rok vydání:	1980
Předmět:	Male B-Lymphocytes Leukocyte Count Lymphoma Agammaglobulinemia Lymphopenia T-Lymphocytes Humans Female Lymphocytes gamma-Globulins Middle Aged Prognosis
Zdroj:	Cancer. 46(8)
ISSN:	0008-543X
Popis:	The total lymphocyte, T, B, and null cell content of peripheral blood from 32 healthy individuals and 30 patients with non-Hodgkin's lymphoma was determined. The patients had a significant reduction of B cells (complement receptor and membrane immunoglobulin positive cells) and a significant reduction in T cells. Correlation of patients' characteristics with lymphocyte abnormalities demonstrated several findings. Patients with advanced disease (III and IV) had significantly lower total lymphocyte and T cells than patients with localized disease (I and II) or normal controls. Patients with hypogammaglobulinemia had lower total lymphocyte and T cells than patients with normal gamma globulin status or normal controls. Patients with diffuse histology and B symptoms had lower total lymphocyte and T cells than normal controls. Discriminant analysis of lymphocyte populations categorized patients by disease extent and gamma globulin status with 70 and 68% accuracy, respectively.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::f42b5963b4858d71e6d82027d1603a87 https://pubmed.ncbi.nlm.nih.gov/6159065 Zobrazit plný text záznamu Plný text