Strain-specific spleen remodelling in Plasmodium yoelii infections in Balb/c mice facilitates adherence and spleen macrophage-clearance escape
| Autor: | Martin-Jaular, Lorena, Ferrer, Mireia, Calvo, Maria, Rosanas-Urgell, Anna, Kalko, Susana, Graewe, Stefanie, Soria, Guadalupe, Cortadellas, Núria, Ordi, Jaume, Planas, Anna, Burns, James, Heussler, Volker, del Portillo, Hernando A |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | Cellular Microbiology |
| ISSN: | 1462-5822 1462-5814 |
| Popis: | Knowledge of the dynamic features of the processes driven by malaria parasites in the spleen is lacking. To gain insight into the function and structure of the spleen in malaria, we have implemented intravital microscopy and magnetic resonance imaging of the mouse spleen in experimental infections with non-lethal (17X) and lethal (17XL) Plasmodium yoelii strains. Noticeably, there was higher parasite accumulation, reduced motility, loss of directionality, increased residence time and altered magnetic resonance only in the spleens of mice infected with 17X. Moreover, these differences were associated with the formation of a strain-specific induced spleen tissue barrier of fibroblastic origin, with red pulp macrophage-clearance evasion and with adherence of infected red blood cells to this barrier. Our data suggest that in this reticulocyte-prone non-lethal rodent malaria model, passage through the spleen is different from what is known in other Plasmodium species and open new avenues for functional/structural studies of this lymphoid organ in malaria. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|