Ryanodine receptor modification and regulation by intracellular Ca
| Autor: | K, Walweel, P, Molenaar, M S, Imtiaz, A, Denniss, C, Dos Remedios, D F, van Helden, A F, Dulhunty, D R, Laver, N A, Beard |
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| Rok vydání: | 2016 |
| Předmět: |
Heart Failure
Heart Ventricles Myocardium Intracellular Space Ryanodine Receptor Calcium Release Channel Tacrolimus Binding Proteins Sarcoplasmic Reticulum Case-Control Studies Humans Calcium Magnesium Myocytes Cardiac Calcium Signaling Phosphorylation Protein Processing Post-Translational Protein Binding |
| Zdroj: | Journal of molecular and cellular cardiology. 104 |
| ISSN: | 1095-8584 |
| Popis: | Heart failure is a multimodal disorder, of which disrupted CaTo assess CaThe function of RyR2 from left ventricular samples was assessed using lipid bilayer single-channel measurements, whilst RyR2 modification and protein:protein interactions were determined using Western Blots and co-immunoprecipitation. In all failing hearts there was an increase in RyR2 activity at end-diastolic cytoplasmic CaDespite different aetiologies, disrupted RyR2 Ca |
| Databáze: | OpenAIRE |
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