| Popis: |
Propofol is an intravenous anesthetic that can be used for the induction and maintenance of anesthesia. In the present study, it was aimed to investigate the mechanism of vasodilator action of propofol in the rat aorta (RA).The RA rings were suspended in isolated organ baths and tension was recorded isometrically. First, potassium chloride (KCl) and phenylephrine (PE) were added to organ baths to form precontraction. When the precontractions were stable, propofol (1, 10, and 100 μM) was added cumulatively to the baths. The antagonistic effect of propofol on KCl (45 mM), PE (1 μM), 5-hydroxytryptamine (5-HT) (30 μM), and calcium chloride (CaClPreincubation with propofol (1, 10, and 100 μM) did not affect the basal tone but inhibited the contraction induced by KCl, PE, 5-HT, and CaClThe propofol induces relaxation in contracted RA and inhibits KCl, PE, 5-HT, and CaCl |
