Prefrontal cortical dopamine release in clinical high risk for psychosis during a cognitive task: a [

Autor:	Abanti, Tagore, Christin, Schifani, Naren, Rao, Huai-Hsuan, Tseng, Konstantine K, Zakzanis, Pablo M, Rusjan, Sylvain, Houle, Romina, Mizrahi
Rok vydání:	2018
Předmět:	Adult Male Risk Pyrrolidines Adolescent Dopamine Prefrontal Cortex Prodromal Symptoms Motor Activity Neuropsychological Tests Gyrus Cinguli Magnetic Resonance Imaging Young Adult Cognition Psychotic Disorders Positron-Emission Tomography Salicylamides Humans Female Radiopharmaceuticals
Zdroj:	European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 29(9)
ISSN:	1873-7862
Popis:	Research suggests decreased cortical dopamine is a neural correlate of cognitive deficits in schizophrenia. Evidence of impaired cognitive task-induced cortical dopamine release was demonstrated in patients with psychosis. However, whether cortical dopamine release in response to a cognitive task in clinical high risk for psychosis (CHR) is also impaired, is currently unknown. We aimed to test dopamine release in the dorsolateral prefrontal cortex (DLPFC) and the anterior cingulate cortex (ACC) in antipsychotic-free CHR participants and healthy controls (HC) performing the Wisconsin Card Sorting Task (WCST). Two [
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::f3f2ecebb3b109de86c769ec04fc294e https://pubmed.ncbi.nlm.nih.gov/31351843 Zobrazit plný text záznamu Full Text from ScienceDirect