The pharmacology of a new hypoglycaemic agent N-[4-(2-(2,3-dihydrobenzo(b)furan-7-carboxamid o)-ethyl)-benzenesulphonyl]-N'-cyclohexlurea (NOVO CS 476). III. General pharmacological studies

Autor:	K D, Jorgensen
Rok vydání:	1977
Předmět:	Male Chlorpropamide Tolbutamide Guinea Pigs Blood Pressure Heart Muscle Smooth Papillary Muscles Diuresis Rats Dogs Sulfonylurea Compounds Glyburide Cats Animals Hypoglycemic Agents Female Muscle Contraction
Zdroj:	Acta pharmacologica et toxicologica. 40(2)
ISSN:	0001-6683
Popis:	The new sulphonylurea CS 476 was tested for positive iontropic effect on the isolated cat papillary muscle. Unlike tolbutamide CS 476 had no positive inotropic effect. CS 476 had no adverse effect on blood pressure in dogs, cats and rats nor on the electrocardiogram of dogs in doses up to ten times the therapeutic dose. Unlike chlorpromide CS 476 did not potentiate the effect of exogenous antidiuretic hormone in hydrated dogs. In therapeutic concentrations the drug had no effect on smooth muscle preparations. 1,000-10,000 times therapeutic concentrations had a papaverine-like effect - similar to therapeutic concentrations of tolbutamide.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::f3ef0f10928370c7d5d72e08c490ab63 https://pubmed.ncbi.nlm.nih.gov/402792 Zobrazit plný text záznamu Plný text