Indeterminate pediatric acute liver failure is uniquely characterized by a CD103

Autor:	Catherine A, Chapin, Thomas, Burn, Tomas, Meijome, Kathleen M, Loomes, Hector, Melin-Aldana, Portia A, Kreiger, Peter F, Whitington, Edward M, Behrens, Estella M, Alonso
Rok vydání:	2017
Předmět:	Male Adolescent Infant CD8-Positive T-Lymphocytes Liver Failure Acute Antigens CD Child Preschool Humans Female Prospective Studies Child Immunologic Memory Integrin alpha Chains Retrospective Studies
Zdroj:	Hepatology (Baltimore, Md.). 68(3)
ISSN:	1527-3350
Popis:	The cause of pediatric acute liver failure (PALF) is unknown in up to 40% of cases. Evidence suggests that aberrant immune system activation may play a role. We hypothesized that indeterminate PALF cases would exhibit a unique pattern of hepatic inflammation. This was a retrospective and prospective study of PALF cases due to indeterminate (iPALF), autoimmune hepatitis, or known diagnosis (dPALF) etiology. Liver tissue sections were stained with immunohistochemical markers for cytotoxic T-cells (cluster of differentiation 8 [CD8]), perforin, and tissue resident memory T-cells (CD103) and scored as minimal, moderate, or dense. Lymphocytes were isolated from liver tissue for T-cell receptor beta sequencing and flow-cytometric studies. Thirty-three iPALF, 9 autoimmune hepatitis, and 14 dPALF cases were included. Dense hepatic infiltrates of CD8Indeterminate PALF is characterized by a dense CD8
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::f3c5941713269f7508425935bfc006fa https://pubmed.ncbi.nlm.nih.gov/29603342 Zobrazit plný text záznamu Plný text