Placental growth hormone and IGF-I in a pregnant woman with Pit-1 deficiency

Autor:	J, Verhaeghe, M, Bougoussa, E, Van Herck, F, de Zegher, G, Hennen, A, Igout
Rok vydání:	2000
Předmět:	Adult Fetal Blood DNA-Binding Proteins Pregnancy Complications Pituitary Hormones Thyroxine Hypothyroidism Pregnancy Humans Female Immunoradiometric Assay Insulin-Like Growth Factor I Placental Hormones Transcription Factor Pit-1 Transcription Factors
Zdroj:	Clinical endocrinology. 53(5)
ISSN:	0300-0664
Popis:	The respective contributions of pituitary and placental GH to circulating IGF-I in pregnant women have not been well established. We measured the serum concentrations of placental growth hormone (PGH) and IGF-I in a woman with pit-1 deficiency before, during and after pregnancy, resulting in the birth of a healthy child (not pit-1 deficient). Both PGH and IGF-I concentrations were below the assay detection limit before and after pregnancy. During pregnancy, PGH and IGF-I levels increased steadily; the concentrations of PGH and IGF-I in late pregnancy were comparable with levels previously measured in normal pregnancies. PGH and IGF-I concentrations were strongly correlated throughout pregnancy (r = 0.90; P = 0.002). PGH was undetectable in cord serum, whilst the IGF-I concentration was within the normal range. The findings of this case study corroborate the notion that PGH is the prime regulator of maternal serum IGF-I during pregnancy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::f35c942899ff0d0c61203e1ece915a70 https://pubmed.ncbi.nlm.nih.gov/11106927 Zobrazit plný text záznamu Plný text