| Autor: |
V I, Kocherga, N V, Nesterenko, L K, Kurchenko, V A, Afanas'ev |
| Rok vydání: |
1991 |
| Předmět: |
|
| Zdroj: |
Farmakologiia i toksikologiia. 54(5) |
| ISSN: |
0014-8318 |
| Popis: |
The activating effect of a M-receptor agonist carbachol on phosphatidylinositol metabolism under perfusion of the isolated rabbit heart with 32Pi was shown. An increase of the inclusion of 32P in phosphatidylinositol-4-phosphate and phosphatidylinositol-4-diphosphate was found. Simultaneously there was detected an elevation of the levels of products of hydrolysis of inositol phospholipids--inositol-1,4-diphosphate and inositol-1,4,5-triphosphate. There was noted the blocking action of carbachol on the contractile activity of the heart that manifested itself in a lowering of the systolic pressure in the left ventricle and a slowing of the contraction rate. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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